Shaklee Life+ Collagen Support

Liquid BioCell® Life+

Triple-Action Collagen Support for Lifelong Resilience*

Joints that move freely. Skin that looks firm & smooth. A body that feels like it’s working with you. Shaklee Life+ collagen is formulated to support your entire collagen lifecycle in three dimensions: protect what you have, stimulate renewal, & build what’s weakening.* Powered by patent-pending TriPlex Technology™, featuring award-winning Collagen/HA Matrix® plus precision-targeted bioactives. This isn’t just collagen; this is transformation. Redefine how you move, look & feel to live age free.*

Shaklee Life+ Benefits:

The expertly selected ingredients in Liquid BioCell® Life+ have been studied for their roles in supporting: 

• Joint comfort and mobility* 
• Bone density and structural strength* 
• Cartilage integrity* 
• Skin hydration and visible smoothness* 
• Connective tissue strength and resilience* 
• Wrinkle reduction and healthy hair, skin, and nails*

What is Triplex Technology™?

TriPlex Technology™ is the patent-pending system behind Liquid BioCell Life+ that supports collagen across its complete lifecycle.* It features the clinically studied Collagen/HA Matrix enhanced with targeted bioactive ingredients, including calcium fructoborate, pine bark extract, and fucoidan.

Liquid BioCell®

This patented Collagen/HA Matrix® pioneered the liquid collagen category by mirroring human cartilage at its source–delivering collagen micropeptides, hyaluronic acid, and chondroitin sulfate in a naturally coexisting matrix. Clinically studied to support the body’s natural collagen renewal processes, it also helps maintain and protect the hydrated environment where collagen thrives.^* This foundational matrix supports collagen integrity, connective tissue resilience, and visible wrinkle reduction.^*1,2,3,4,5,6

Calcium Fructoborate 

A naturally derived, bioavailable source of calcium and boron that helps support bone density and mineral balance.^* Because collagen forms the flexible framework of bone, maintaining proper mineral support helps reinforce the structural environment that gives bones their strength and resilience.^{*7,8,9,10,13,16,17}

Pine Bark Extract

A potent, plant-based antioxidant that helps protect cells from oxidative stress.^* By helping neutralize free radicals, pine bark supports the preservation of existing collagen and helps maintain the health of collagen-supporting cells.^*15 

Fucoidan

This bioactive marine-derived polysaccharide helps support healthy, balanced inflammatory responses within connective tissue.^* Excessive inflammatory stress can disrupt collagen structures and increase the production of enzymes that contribute to breakdown. By maintaining a healthy tissue environment where collagen fibers can form and organize properly, fucoidan supports the natural processes that build and protect collagen over time.^*14  

Biotin

This essential B vitamin helps convert nutrients into cellular energy the body can use.^* By supporting energy production within collagen-producing cells, biotin helps sustain the renewal processes that maintain connective tissue health.^*11 

Zinc 

An essential trace mineral and cofactor for enzymes involved in collagen formation. Zinc supports antioxidant defenses and helps maintain the natural processes that support collagen structure and renewal.^* 

How is Shaklee Life+ Different from Other Collagens?

Most collagen supplements simply target replenishment, but Life+ is formulated to support collagen across its complete lifecycle.* Its exclusive TriPlex Technology helps protect existing collagen, stimulate natural collagen renewal, and build the supportive environment collagen needs to remain strong and resilient.*

• Protect – Polyphenol antioxidants help neutralize free radicals and support healthy, balanced inflammatory signaling, protecting existing collagen from everyday breakdown caused by oxidative stress.*
• Stimulate –  Bioactive collagen peptides act as signaling molecules that help stimulate collagen-producing cells, supporting the body’s natural collagen renewal as production slows with age.*
• Build – Hyaluronic acid and chondroitin sulfate help maintain the hydrated, cushioning extracellular environment surrounding collagen fibers, while essential nutrients support the structural framework of connective tissue and bone.*

1. Schwartz SR, Park J. Ingestion of BioCell Collagen(®), a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clin Interv Aging. 2012;7:267-73.
2. Schwartz SR, Hammon KA, Gafner A, Dahl A, Guttman N, Fong M, Schauss AG. Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial. Altern Ther Health Med. 2019 Sep;25(5):12-29.
3. Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. J Agric Food Chem. 2012 Apr 25;60(16):4096-101.
4. Lopez HL, Ziegenfuss TN, Park J. Evaluation of the Effects of BioCell Collagen, a Novel Cartilage Extract, on Connective Tissue Support and Functional Recovery From Exercise. Integr Med (Encinitas). 2015 Jun;14(3):30-8.
5. Oesser S, Seifert J. Stimulation of type II collagen biosynthesis and secretion in chondrocytes cultured with degraded collagen. Cell Tissue Res. 2003;311(3):393–399.
6. Judy WV, Stogsdill WW. Peak Absorption Characteristics and steady state bioavailability of product containing hyaluronic acid and chondroitin from BioCell Collagen II. Confidential Report
7. Reyes-Izquierdo T., et al. (2011). Short-term Intake of Calcium Fructoborate Improves WOMAC and McGill Scores and Beneficially Modulates Biomarkers Associated with Knee Osteoarthritis: A Pilot Clinical Double-blinded Placebo-controlled Study. American Journal of Biomedical Sciences.
8. Pietrzkowski Z., et al. (2014). Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study. Clinical Interventions in Aging.
9. Pietrzkowski Z., et al (2018). Effects of once-daily versus twice daily dosing of calcium fructoborate on knee discomfort. A 90 day, double-blind, placebo controlled randomizec clinical study. The Journal of Aging Research and Lifestyle.
10. Robinson J., et al (2023). Impact of Calcium Fructoborate on WOMAC and McGill Subscales and Individual WOMAC Questions: Post-Hoc Analyses of Data from a Previously Published 90-Day Randomized Clinical Trial. European Journal of Applied Sciences.
11. Floersheim GL. Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Z Hautkr. 1989 Jan 15;64(1):41-8. German.
12. Kelly et al. Effect of keraGEN IV Keratin oral supplementation on hair, skin, and nail attributes, Lincoln Agritech Ltd and R J Kelly Consulting LTD.; Lincoln, New Zealand, HealthMED, Volume 18, Number 2, 2024.
13. Rondanelli M, Faliva MA, Peroni G, Infantino V, Gasparri C, Iannello G, Perna S, Riva A, Petrangolini G, Tartara A. Pivotal role of boron supplementation on bone health: A narrative review. J Trace Elem Med Biol. 2020 Dec;62:126577.
14. Jackson CJ, Giles I, Knop A, Nethery A, Schrieber L. Sulfated polysaccharides are required for collagen-induced vascular tube formation. Exp Cell Res. 1994 Dec;215(2):294-302
15. Jung HY, Shin JC, Park SM, Kim NR, Kwak W, Choi BH. Pinus densiflora extract protects human skin fibroblasts against UVB-induced photoaging by inhibiting the expression of MMPs and increasing type I procollagen expression. Toxicol Rep. 2014 Aug 29;1:658-666.
16. Rababah T, Aludatt M, Gammoh S, Salameh FB, Magableh G, Almajwal A, Yücel S, Al-Rayyan Y, Al-Rayyan N. A pilot study investigating the influence of dietary boron levels on osteoporosis in postmenopausal women. Food Sci Nutr. 2024 May 19;12(8):5708-5721
17. Yan T, Wang P, Cao Z. Calcium Fructoborate Improves Knee Osteoarthritis in Rats by Activating Hedgehog Signaling Through DDIT3. Biol Trace Elem Res. 2025 Jul;203(7):3803-3819.
    
    *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.